Factor IX alteration p.Arg338Gln (FIX Shanghai) potentiates FIX clotting activity and causes thrombosis
نویسندگان
چکیده
منابع مشابه
Incorporation of the factor IX Padua mutation into FIX-Triple improves clotting activity in vitro and in vivo.
Using gain-of-function factor IX (FIX) for replacement therapy for haemophilia B (HB) is an attractive strategy. We previously reported a high-activity FIX, FIX-Triple (FIX-V86A/E277A/R338A) as a good substitute for FIX-WT (wild-type) in protein replacement therapy, gene therapy, and cell therapy. Here we generated a new recombinant FIX-TripleL (FIX-V86A/E277A/R338L) by replacing the alanine at...
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The present study sought to determine the impact of the route of administration of an adeno-associated virus (AAV) vector encoding human factor IX (hFIX) on the induction of an immune response against the vector and its xenogenic transgene product, hFIX. Increasing doses of AAV-hFIX were administered by different routes to C57Bl/6 mice, which typically demonstrate significant immune tolerance t...
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This paper presents the results of a measurement study of the T1 NSFNET backbone. We rst discuss the measurement environment and approach to data collection. We then present measurements results for: long-term growth in traac volume, including attribu-tion to domains and protocols; trend in average packet size on the network, both over long and medium term intervals; most popular sources, desti...
متن کاملNON-MEASURABLE SETS AND THE EQUATION fix+y)=fix)+fiy)
1. A set of S real numbers which has inner measure m*(S) different from its outer measure m*iS) is non-measurable. An extreme form, which we shall call saturated non-measurability, occurs when ra*(S)=0 but m*iSM)=miM) for every measurable set M, miM) denoting the measure of M. This is equivalent to: both S and its complement have zero inner measure. More generally, if a fixed set B of positive ...
متن کاملExtravascular FIX and coagulation
This review summarizes the evidence that collagen IV binding is physiologically important, and that the extravascular compartment of FIX is composed of type IV collagen. As we have previously demonstrated, 7 days post-infusion, FIXWT (BeneFIX) is able to control bleeding as well as the same dosage of Alprolix in hemophilia B mice, tested using the saphenous vein bleeding model (Alprolix is a ch...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2020
ISSN: 1592-8721,0390-6078
DOI: 10.3324/haematol.2019.216713